Resting Discharge Patterns of Macular Primary Afferents in Otoconia-Deficient Mice
Identifieur interne : 000652 ( Main/Exploration ); précédent : 000651; suivant : 000653Resting Discharge Patterns of Macular Primary Afferents in Otoconia-Deficient Mice
Auteurs : T. A. Jones [États-Unis] ; S. M. Jones [États-Unis] ; L. F. Hoffman [États-Unis]Source :
- JARO: Journal of the Association for Research in Otolaryngology [ 1525-3961 ] ; 2008.
Abstract
Vestibular primary afferents in the normal mammal are spontaneously active. The consensus hypothesis states that such discharge patterns are independent of stimulation and depend instead on excitation by vestibular hair cells due to background release of synaptic neurotransmitter. In the case of otoconial sensory receptors, it is difficult to test the independence of resting discharge from natural tonic stimulation by gravity. We examined this question by studying discharge patterns of single vestibular primary afferent neurons in the absence of gravity stimulation using two mutant strains of mice that lack otoconia (OTO−;
Url:
DOI: 10.1007/s10162-008-0132-0
PubMed: 18661184
PubMed Central: 2580812
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000110
- to stream Pmc, to step Curation: 000110
- to stream Pmc, to step Checkpoint: 000174
- to stream Ncbi, to step Merge: 000127
- to stream Ncbi, to step Curation: 000127
- to stream Ncbi, to step Checkpoint: 000127
- to stream Main, to step Merge: 000661
- to stream Main, to step Curation: 000652
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Resting Discharge Patterns of Macular Primary Afferents in Otoconia-Deficient Mice</title>
<author><name sortKey="Jones, T A" sort="Jones, T A" uniqKey="Jones T" first="T. A." last="Jones">T. A. Jones</name>
<affiliation wicri:level="2"><nlm:aff id="Aff1">Communication Sciences and Disorders, School of Allied Health Sciences, East Carolina University, Health Sciences Building, Rm 3310P, Greenville, NC 27858-4353 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
<wicri:cityArea>Communication Sciences and Disorders, School of Allied Health Sciences, East Carolina University, Health Sciences Building, Rm 3310P, Greenville</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="Aff2">Division of Head and Neck Surgery and Brain Research Institute, Geffen School of Medicine at UCLA, Los Angeles, CA 90095-1624 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Division of Head and Neck Surgery and Brain Research Institute, Geffen School of Medicine at UCLA, Los Angeles</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Jones, S M" sort="Jones, S M" uniqKey="Jones S" first="S. M." last="Jones">S. M. Jones</name>
<affiliation wicri:level="2"><nlm:aff id="Aff1">Communication Sciences and Disorders, School of Allied Health Sciences, East Carolina University, Health Sciences Building, Rm 3310P, Greenville, NC 27858-4353 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
<wicri:cityArea>Communication Sciences and Disorders, School of Allied Health Sciences, East Carolina University, Health Sciences Building, Rm 3310P, Greenville</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Hoffman, L F" sort="Hoffman, L F" uniqKey="Hoffman L" first="L. F." last="Hoffman">L. F. Hoffman</name>
<affiliation wicri:level="2"><nlm:aff id="Aff2">Division of Head and Neck Surgery and Brain Research Institute, Geffen School of Medicine at UCLA, Los Angeles, CA 90095-1624 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Division of Head and Neck Surgery and Brain Research Institute, Geffen School of Medicine at UCLA, Los Angeles</wicri:cityArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">18661184</idno>
<idno type="pmc">2580812</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2580812</idno>
<idno type="RBID">PMC:2580812</idno>
<idno type="doi">10.1007/s10162-008-0132-0</idno>
<date when="2008">2008</date>
<idno type="wicri:Area/Pmc/Corpus">000110</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000110</idno>
<idno type="wicri:Area/Pmc/Curation">000110</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000110</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000174</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000174</idno>
<idno type="wicri:Area/Ncbi/Merge">000127</idno>
<idno type="wicri:Area/Ncbi/Curation">000127</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000127</idno>
<idno type="wicri:doubleKey">1525-3961:2008:Jones T:resting:discharge:patterns</idno>
<idno type="wicri:Area/Main/Merge">000661</idno>
<idno type="wicri:Area/Main/Curation">000652</idno>
<idno type="wicri:Area/Main/Exploration">000652</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Resting Discharge Patterns of Macular Primary Afferents in Otoconia-Deficient Mice</title>
<author><name sortKey="Jones, T A" sort="Jones, T A" uniqKey="Jones T" first="T. A." last="Jones">T. A. Jones</name>
<affiliation wicri:level="2"><nlm:aff id="Aff1">Communication Sciences and Disorders, School of Allied Health Sciences, East Carolina University, Health Sciences Building, Rm 3310P, Greenville, NC 27858-4353 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
<wicri:cityArea>Communication Sciences and Disorders, School of Allied Health Sciences, East Carolina University, Health Sciences Building, Rm 3310P, Greenville</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="Aff2">Division of Head and Neck Surgery and Brain Research Institute, Geffen School of Medicine at UCLA, Los Angeles, CA 90095-1624 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Division of Head and Neck Surgery and Brain Research Institute, Geffen School of Medicine at UCLA, Los Angeles</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Jones, S M" sort="Jones, S M" uniqKey="Jones S" first="S. M." last="Jones">S. M. Jones</name>
<affiliation wicri:level="2"><nlm:aff id="Aff1">Communication Sciences and Disorders, School of Allied Health Sciences, East Carolina University, Health Sciences Building, Rm 3310P, Greenville, NC 27858-4353 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
<wicri:cityArea>Communication Sciences and Disorders, School of Allied Health Sciences, East Carolina University, Health Sciences Building, Rm 3310P, Greenville</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Hoffman, L F" sort="Hoffman, L F" uniqKey="Hoffman L" first="L. F." last="Hoffman">L. F. Hoffman</name>
<affiliation wicri:level="2"><nlm:aff id="Aff2">Division of Head and Neck Surgery and Brain Research Institute, Geffen School of Medicine at UCLA, Los Angeles, CA 90095-1624 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Division of Head and Neck Surgery and Brain Research Institute, Geffen School of Medicine at UCLA, Los Angeles</wicri:cityArea>
</affiliation>
</author>
</analytic>
<series><title level="j">JARO: Journal of the Association for Research in Otolaryngology</title>
<idno type="ISSN">1525-3961</idno>
<idno type="eISSN">1438-7573</idno>
<imprint><date when="2008">2008</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>Vestibular primary afferents in the normal mammal are spontaneously active. The consensus hypothesis states that such discharge patterns are independent of stimulation and depend instead on excitation by vestibular hair cells due to background release of synaptic neurotransmitter. In the case of otoconial sensory receptors, it is difficult to test the independence of resting discharge from natural tonic stimulation by gravity. We examined this question by studying discharge patterns of single vestibular primary afferent neurons in the absence of gravity stimulation using two mutant strains of mice that lack otoconia (OTO−; <italic>head tilt</italic>
, <italic>het-Nox3</italic>
, and <italic>tilted</italic>
, <italic>tlt-Otop1</italic>
). Our findings demonstrated that macular primary afferent neurons exhibit robust resting discharge activity in OTO− mice. Spike interval coefficient of variation (CV = SD/mean spike interval) values reflected both regular and irregular discharge patterns in OTO− mice, and the range of values for rate-normalized CV was similar to mice and other mammals with intact otoconia although there were proportionately fewer irregular fibers. Mean discharge rates were slightly higher in otoconia-deficient strains even after accounting for proportionately fewer irregular fibers [OTO− = 75.4 ± 31.1(113) vs OTO+ = 68.1 ± 28.5(143) in sp/s]. These results confirm the hypothesis that resting activity in macular primary afferents occurs in the absence of ambient stimulation. The robust discharge rates are interesting in that they may reflect the presence of a functionally ‘up-regulated’ tonic excitatory process in the absence of natural sensory stimulation.</p>
</div>
</front>
</TEI>
<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>Californie</li>
<li>Caroline du Nord</li>
</region>
</list>
<tree><country name="États-Unis"><region name="Caroline du Nord"><name sortKey="Jones, T A" sort="Jones, T A" uniqKey="Jones T" first="T. A." last="Jones">T. A. Jones</name>
</region>
<name sortKey="Hoffman, L F" sort="Hoffman, L F" uniqKey="Hoffman L" first="L. F." last="Hoffman">L. F. Hoffman</name>
<name sortKey="Jones, S M" sort="Jones, S M" uniqKey="Jones S" first="S. M." last="Jones">S. M. Jones</name>
<name sortKey="Jones, T A" sort="Jones, T A" uniqKey="Jones T" first="T. A." last="Jones">T. A. Jones</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Eau/explor/LotaV3/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000652 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000652 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Eau |area= LotaV3 |flux= Main |étape= Exploration |type= RBID |clé= PMC:2580812 |texte= Resting Discharge Patterns of Macular Primary Afferents in Otoconia-Deficient Mice }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:18661184" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \ | NlmPubMed2Wicri -a LotaV3
This area was generated with Dilib version V0.6.39. |